产品英文名称：PE Mouse Anti-Human CD10
产品中文名称：PE鼠抗人CD10
BD PE鼠抗人CD10 PE Mouse Anti-Human CD10产品英文描述：
Catalog Number 347653
Name Cytokeratin
Size 100 Tests
Regulatory Status RUO (GMP)
List Price Inquire
Related Molecules KRT7
Clone CAM 5.2
Format FITC
Isotype IgG2a, κ
W.S. No none
W.B. Positive Control none
Molecular Weight none
Reactivity QC Testing : Human
Applications Routinely Tested:Intracellular staining (flow cytometry)
Reacts with neutral endopeptidase, a 100 kDa type II transmembrane glycoprotein, otherwise known as the common acute lymphoblastic
leukemia antigen (CALLA). CD10 is expressed on a wide variety of normal and neoplastic cell types. Normal cells expressing CD10 include
granulocytes, a subset of B-cell progenitors, germinal center cells and fibroblasts.
Clone - Description
Anti-Cytokeratin (CAM 5.2) reagent has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 kDa, respectively.Cytokeratin 7 and 8 are present on secretory epithelia of normal human tissue but not on stratified squamous epithelium. Anti-Cytokeratin (CAM 5.2) stains most epithelial-derived tissue, including liver, renal tubular epithelium, and hepatocellular and renal cell carcinomas. Anti-Cytokeratin (CAM 5.2) may not react with some squamous cell carcinomas.
BD PE鼠抗人CD10 PE Mouse Anti-Human CD10单克隆抗体多样性的遗传学基础：
L链H链相互随机配对 如表2-6所示，小鼠H链和κ链随机配对后推算其多样性可达4.8×107，如果再加上H链与λ链的随机配对其多样性应更多了。
产品规格：0.1ml/0.2ml
储 存： -20℃环境下存放. 封闭保存,否则会降低产品含量.
产品用途：本产品仅供科研使用，不做其他用途
产品价格：电询咨询
基因重排：
1）抗体的L链是由C、V、J三个基因簇编码的，H链由C、V、D、J四个基因簇编码的。
2）V是编码可变区，有300个种类;D编码高变区,有15 ～ 20个种类;J编码连接V、C的结合区，有4～5个种类;C编码恒定区，仅有一种。
3）这些外显子通过多种多样的重排，所合成出的肽链，还要再进一步进行L和H链组合，这样zui后生成的抗体种类就非常多了。
4）抗体基因重排是发生在淋巴细胞分化的时候
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